2016 Nov 8;7(45):73323-73336. doi: 10.18632/oncotarget.12331. Li G, Wang C, Yang M, Cao L, Fu D, Liu X, Sun D, Chen C, Wang Y, Jia Z, Yang C, Guo Y, Rao Z. J Virol. [7] Typically, each subunit forms an eight-stranded barrel that swaps C-terminal β-strands with the other subunits to assemble into the trimer structure. Nous contacter Jones NK, Arab NT, Eid R, Gharib N, Sheibani S, Vali H, Khoury C, Murray A, Boucher E, Mandato CA, Young PG, Greenwood MT. Heterologous expression of anti-apoptotic human 14-3-3β/α enhances iron-mediated programmed cell death in yeast. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Of interest, cell death was not prevented under culture conditions modeling chronological aging, suggesting that DUT-M only protects dividing cells.

What is the canonical sequence?

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canonicali sequence. Renseignements suite à un email de description de votre projet. Using yeast as a model of eukaryotic mitochondrial apoptosis, we show that a cDNA corresponding to the mitochondrial variant of the human DUT gene (DUT-M) encoding the deoxyuridine triphosphatase (dUTPase) enzyme can prevent apoptosis in yeast in response to internal (Bax expression) and to exogenous (H2O2 and cadmium) stresses. Sci. Jouer, Dictionnaire de la langue françaisePrincipales Références. … The current subsections and their content are listed below:

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.

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This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is in its mature form or if it represents the precursor.

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This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). This enzyme participates in pyrimidine metabolism. Priority is given to the annotation of physiological ligands.

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, dUTP; via amide nitrogen and carbonyl oxygen,

Manually validated information inferred from a combination of experimental and computational evidence.

Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max),

Manually curated information for which there is published experimental evidence.

There are at least two structurally distinct families of dUTPases. Please enable it to take advantage of the complete set of features! Apoptosis in yeast: a new model for aging research. Changer la langue cible pour obtenir des traductions. Odat O, Matta S, Khalil H, Kampranis SC, Pfau R, Tsichlis PN, Makris AM. [8] This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. Chaque lettre qui apparaît descend ; il faut placer les lettres de telle manière que des mots se forment (gauche, droit, haut et bas) et que de la place soit libérée. 1Q5H, 1Q5U, 2HQU, 3ARA, 3ARN, 3EHW, 4MZ5, 4MZ6, NM_001025248NM_001025249NM_001948NM_001330286, NP_001020419NP_001020420NP_001317215NP_001939, DUTP pyrophosphatase, also known as DUT, is an enzyme which in humans is encoded by the DUT gene on chromosome 15.

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When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.

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This indicates the type of evidence that supports the existence of the protein. Structural Insight into African Swine Fever Virus dUTPase Reveals a Novel Folding Pattern in the dUTPase Family. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.

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This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e. Les lettres doivent être adjacentes et les mots les plus longs sont les meilleurs. En savoir plus, Bertani Le., Haeggmark A., Reichard P. (1963). [4], In humans, this gene encodes a homotrimeric enzyme with two isoforms characterized by their distinct subcellular localizations: the nuclear isoform (DUT-N) and mitochondrial isoform (DUT-M). The anti-apoptotic function of DUT-M was confirmed by demonstrating that an increase in dUTPase protein levels is sufficient to confer increased resistance to H(2)O(2) in cultured C2C12 mouse skeletal myoblasts. USA.gov. Polymerase Chain Reaction (PCR) is a technique that uses DNA polymerase to amplify a single strand or segment of DNA. Astuce: parcourir les champs sémantiques du dictionnaire analogique en plusieurs langues pour mieux apprendre avec sensagent. All positional information in this entry refers to it. The ligands are bound between subunits, and for each substrate molecule, residues from adjacent subunits contribute to the binding interactions. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.

Examples: P92958, Q8TDN4, O14734

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. Tous droits réservés. Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. SwissPalm database of S-palmitoylation events, Bgee dataBase for Gene Expression Evolution, ExpressionAtlas, Differential and Baseline Expression, Genevisible search portal to normalized and curated expression data from Genevestigator, The Biological General Repository for Interaction Datasets (BioGRID), Protein interaction database and analysis system, STRING: functional protein association networks, BindingDB database of measured binding affinities. Other names in common use include deoxyuridine-triphosphatase, dUTPase, dUTP pyrophosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, and desoxyuridine 5'-triphosphatase.  | 

Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.

○   jokers, mots-croisés  | Dernières modifications. ► The anti-apoptotic function of dUTPase suggests that dUTP is a pro-apoptotic second messenger that serves to mediate the effects of stress on cell death. This site needs JavaScript to work properly. Natl. Get the latest research from NIH: https://www.nih.gov/coronavirus. [3], The second family has a novel all-alpha fold, members of this family are unrelated to the all-beta fold found in dUTPases of the majority of organisms.[4]. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. The crystal structure of human dUTPase reveals that each subunit of the dUTPase trimer folds into an eight-stranded jelly-roll beta barrel, with the C-terminal beta strands interchanged among the subunits. The terms UDG and UNG are commonly used interchangeably because they perform the same function in qPCR—namely to prevent carryover contamination. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. This is known as the 'taxonomic identifier' or 'taxid'.

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This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. This section is only present in reviewed entries, i.e. dUTP is used to replace TTP in the PCR reaction so that all PCR products will contain dUTP. You are using a version of browser that may not display all the features of this website. The systematic name of this enzyme class is dUTP nucleotidohydrolase. Biochem Biophys Res Commun.  | Informations Thus, the two substrates of this enzyme are dUTP and H2O, whereas its two products are dUMP and diphosphate. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.

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This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.

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This subsection of the Names and taxonomy section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.

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Manually curated information that is based on statements in scientific articles for which there is no experimental support.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts. [6] The isoforms are produced from alternative splicing at different 5' exons, with the first exon of DUT-N occurring 767 base pairs downstream of the first exon in DUT-M.[6][7] Regulation at different promoters has been proposed to account for the differential expression of these isoforms. La plupart des définitions du français sont proposées par SenseGates et comportent un approfondissement avec Littré et plusieurs auteurs techniques spécialisés. [6], The mature forms of DUT-N (22 kDa) and DUT-M (23 kDa) are nearly identical except for a short N-terminal region present in DUT-M. DUTP pyrophosphatase, also known as DUT, is an enzyme which in humans is encoded by the DUT gene on chromosome 15.. nucleobase-containing compound metabolic process, nucleobase-containing small molecule interconversion, GRCh38: Ensembl release 89: ENSG00000128951, "Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights", "The human dUTPase gene encodes both nuclear and mitochondrial isoforms. [, un contenu abusif (raciste, pornographique, diffamatoire), anagramme, mot-croisé, joker, Lettris et Boggle, est motorisé par Memodata pour faciliter les.

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